September 18, 2021
Ajax 9 - 0 Cambuur
Willem II 2 - 1 Groningen
Heerenveen 1 - 0 Fortuna Sittard
September 17, 2021
Sparta Rotterdam 1 - 1 NEC
September 12, 2021
RKC Waalwijk 1 - 2 Vitesse
Groningen 1 - 1 Heerenveen
Sparta Rotterdam 3 - 1 Fortuna Sittard
NEC 0 - 0 Willem II
September 11, 2021
AZ 0 - 3 PSV Eindhoven
Cambuur 5 - 2 Go Ahead Eagles
PEC Zwolle 0 - 2 Ajax
Twente 1 - 0 Utrecht
August 29, 2021
Heerenveen 1 - 3 AZ
Heracles Almelo 0 - 1 NEC
Ajax 5 - 0 Vitesse
Utrecht 3 - 1 Feyenoord
August 28, 2021
Willem II 1 - 0 PEC Zwolle
PSV Eindhoven 5 - 2 Groningen
Go Ahead Eagles 2 - 0 Sparta Rotterdam
Cambuur 2 - 0 Twente

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