Frenkie de Jong, Memphis Depay, and Teun Koopmeiners have all left the Netherlands squad after picking up injuries in the win over Poland.
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Koopmeiners suffered a concussion after only a minute of the 2-0 win over Poland, while De Jong and Memphis were also forced off injured.
All three have now left the Netherlands squad to work on their recovery, with Louis van Gaal picking Bayern Munich midfielder Ryan Gravenberch and Ajax striker Brian Brobbey as replacements. It is a first call-up for Brobbey.
Both Gravenberch and Brobbey played for the U21s in their win over Belgium but they now join the main squad.