February 5, 2022
Utrecht 16:30 Cambuur
Fortuna Sittard 18:45 Heerenveen
PEC Zwolle 20:00 NEC
PSV Eindhoven 20:00 AZ
Twente 21:00 Vitesse
February 6, 2022
Feyenoord 12:15 Sparta Rotterdam
Groningen 14:30 Go Ahead Eagles
Willem II 14:30 RKC Waalwijk
Ajax 16:45 Heracles Almelo
February 11, 2022
Heracles Almelo 20:00 Utrecht
February 12, 2022
Go Ahead Eagles 16:30 AZ
Groningen 18:45 Fortuna Sittard
Vitesse 20:00 PSV Eindhoven
Cambuur 21:00 PEC Zwolle
February 13, 2022
Sparta Rotterdam 12:15 Willem II
RKC Waalwijk 14:30 Feyenoord
Heerenveen 14:30 NEC
Ajax 16:45 Twente
February 18, 2022
Fortuna Sittard 20:00 Sparta Rotterdam