January 22, 2021
Willem II 20:00 PEC Zwolle
January 23, 2021
ADO Den Haag 16:30 Emmen
Vitesse 18:45 Groningen
PSV Eindhoven 20:00 RKC Waalwijk
Heracles Almelo 21:00 Heerenveen
January 24, 2021
Fortuna Sittard 12:15 Ajax
Twente 14:30 VVV-Venlo
Utrecht 14:30 Sparta Rotterdam
Feyenoord 16:45 AZ
January 26, 2021
PEC Zwolle 18:45 Heracles Almelo
Emmen 20:00 PSV Eindhoven
Groningen 21:00 ADO Den Haag
January 27, 2021
AZ 18:45 Utrecht
RKC Waalwijk 20:00 Fortuna Sittard
VVV-Venlo 20:00 Vitesse
Heerenveen 21:00 Feyenoord
January 28, 2021
Sparta Rotterdam 18:45 Twente
Ajax 21:00 Willem II