October 7, 2022
Groningen 19:00 RKC Waalwijk
October 8, 2022
FC Volendam 15:30 Ajax
Sparta Rotterdam 17:45 Emmen
NEC 20:00 Excelsior
October 9, 2022
Go Ahead Eagles 11:15 Cambuur
Feyenoord 13:30 Twente
Utrecht 13:30 AZ
Heerenveen 15:45 PSV Eindhoven
Vitesse 19:00 Fortuna Sittard
October 14, 2022
Emmen 19:00 FC Volendam
October 15, 2022
Fortuna Sittard 17:45 RKC Waalwijk
Go Ahead Eagles 19:00 Heerenveen
Cambuur 20:00 Vitesse
October 16, 2022
Sparta Rotterdam 11:15 NEC
PSV Eindhoven 13:30 Utrecht
Twente 13:30 Groningen
AZ 15:45 Feyenoord
Ajax 19:00 Excelsior