August 13, 2021
Go Ahead Eagles 19:00 Heerenveen
August 14, 2021
RKC Waalwijk 15:30 AZ
Heracles Almelo 17:45 PSV Eindhoven
Fortuna Sittard 19:00 Twente
Ajax 20:00 NEC
August 15, 2021
Cambuur 11:15 Groningen
PEC Zwolle 13:30 Vitesse
Utrecht 13:30 Sparta Rotterdam
Willem II 15:45 Feyenoord
August 20, 2021
NEC 19:00 PEC Zwolle
August 21, 2021
Heerenveen 17:45 RKC Waalwijk
PSV Eindhoven 19:00 Cambuur
Sparta Rotterdam 19:00 Heracles Almelo
Groningen 20:00 Utrecht
August 22, 2021
Twente 11:15 Ajax
Feyenoord 13:30 Go Ahead Eagles
Vitesse 13:30 Willem II
AZ 15:45 Fortuna Sittard
August 27, 2021
Fortuna Sittard 19:00 RKC Waalwijk

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