August 7, 2022
AZ 2 - 0 Go Ahead Eagles
Vitesse 2 - 5 Feyenoord
NEC 0 - 1 Twente
Groningen 2 - 2 FC Volendam
August 6, 2022
RKC Waalwijk 2 - 2 Utrecht
PSV Eindhoven 4 - 1 Emmen
Cambuur 0 - 2 Excelsior
Fortuna Sittard 2 - 3 Ajax
August 5, 2022
Heerenveen 0 - 0 Sparta Rotterdam