January 22, 2021
Willem II 1 - 3 PEC Zwolle
January 17, 2021
Ajax 1 - 0 Feyenoord
VVV-Venlo 1 - 1 Heerenveen
Groningen 2 - 2 Twente
RKC Waalwijk 1 - 1 Willem II
January 16, 2021
AZ 2 - 1 ADO Den Haag
Utrecht 2 - 0 Heracles Almelo
PEC Zwolle 0 - 2 Fortuna Sittard
Sparta Rotterdam 3 - 5 PSV Eindhoven
Emmen 1 - 4 Vitesse
January 14, 2021
Willem II 2 - 3 Groningen
Twente 1 - 3 Ajax
Heerenveen 1 - 1 RKC Waalwijk
January 13, 2021
Feyenoord 1 - 0 PEC Zwolle
ADO Den Haag 1 - 4 VVV-Venlo
Fortuna Sittard 0 - 1 Sparta Rotterdam
PSV Eindhoven 1 - 3 AZ
January 12, 2021
Heracles Almelo 4 - 0 Emmen
Vitesse 1 - 0 Utrecht