Teun Koopmeiners is struggling with an injury and has dropped out of the Netherlands squad.
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The AZ Alkmaar captain was an unused substitute during the draw with Spain on Wednesday.
Ons Oranje has now confirmed that Koopmeiners is injured and the 22-year-old has returned home.
Frank de Boer has decided not to call-up a replacement for the midfielder. Netherlands face Bosnia & Herzegovina on Sunday and then Poland next Wednesday.